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Fakultät Bio- und Chemieingenieurwesen

Publikationen

Alle Publikationen der Bioprozesstechnik in wissenschaftlichen Journals auf einen Blick. 

Research IDs:

Prof. Dr. Stephan Lütz: ResearcherIDORCID
Dr. Georg Hubmann: ResearchgateORCID

  • Becker M.; Nowak I.; Hildebrand K.; Lütz S.; Rosenthal K.
    Development of a multi-enzyme cascade for 2′3′-cGAMP synthesis from nucleosides.
    Catalysis Science & Technology 2024 , DOI

  • Behr A.S.; Surkamp J.; Abbaspour E.; Häußler M.; Lütz S.; Pleiss J.; Kockmann N.; Rosenthal K.
    Fluent Integration of Laboratory Data into Biocatalytic Process Simulation Using EnzymeML, DWSIM, and Ontologies.
    Processes 2024 , 12, 547 DOI

  • Steinmetz T.; Lindig A.; Lütz S.; Nett M.
    Molecular Networking-Guided Discovery of Kyonggic Acids in Massilia spp.
    Eur. J. Org. Chem. 2024, e202400017 DOI

  • Nerke P.; Korb J.; Haala F.; Hubmann G.; Lütz S.
    Metabolic bottlenecks of Pseudomonas taiwanensis VLB120 during growth on d-xylose via the Weimberg pathway.
    Metabolic Engineering Communications 2024, e00241 DOI

  • Kinner A.; Lütz S.; Rosenthal K.
    Biocatalytic Screening of the Oxidative Potential of Fungi Cultivated on Plant-Based Resources.
    AppliedChem 2024, 4(3), 282-301 DOI

  • Bartsch T.; Lütz S.; Rosenthal K.
    Cell-free protein synthesis with technical additives – expanding the parameter space of in vitro gene expression.
    Beilstein J. Org. Chem., 2024, 20, 2242-2253 DOI

  • Siedentop R.; Siska M.; Hermes J.; Lütz S.; von Lieres E.; Rosenthal K.
    Avoiding Replicates in Biocatalysis Experiments: Machine Learning for Enzyme Cascade Optimization.
    ChemCatChem, 2024, e202400777 DOI

  • Surkamp J.; Wellmann L.; Lütz S.; Rosenthal K.; Kockmann N.
    Ethanol production using Zymomonas mobilis and in situ extraction in a capillary microreactor.
    Micromaschines, 2024, 15, 1255 DOI

  • Siedentop R., Prenzel T., Waldvogel S.R., Rosenthal K., Lütz S.,
    Reaction Engineering and Comparison of Electroenzymatic and Enzymatic ATP Regeneration Systems. (Coverprofil)
    ChemElectroChem 2023, DOI

  • Lindig A., Schwarz S., Hubmann G., Rosenthal K., Lütz S.,
    Bivariate One Strain Many Compounds Designs Expand the Secondary Metabolite Production Space in Corallococcus coralloides.
    Microorganisms 2023, DOI

  • Siedentop R., Prenzel T., Waldvogel S.R., Rosenthal K., Lütz S.,
    Reaction Engineering and Comparison of Electroenzymatic and Enzymatic ATP Regeneration Systems.
    ChemElectroChem 2023, DOI

  • Rolf J., Handke J., Burzinski F., Lütz S., Rosenthal K.,
    Amino acid balancing for the prediction and evaluation of protein concentrations in cell-free protein synthesis systems.
    Biotechnology Progress 2023, DOI

  • Siedentop R., Siska M., Möller N., Lanzrath H., von Lieres E., Lütz S., Rosenthal K.,
    Bayesian Optimization for an ATP-Regenerating In Vitro Enzyme Cascade.
    Catalysts 2023, DOI

  • Siedentop R.,  Dziennus M.,  Lütz S., Rosenthal K.
    Debottlenecking of an In Vitro Enzyme Cascade Using a Combined Model‐ and Experiment‐Based Approach.
    Chemie Ing. Tech. 2023 DOI

  • Kruth S., Zimmermann C.J.-M., Kuhr K., Hiller W., Lütz S., Pietruszka J., Kaiser M., Nett M.
    Generation of Aurachin Derivatives by Whole-Cell Biotransformation and Evaluation of Their Antiprotozoal Properties. 
    Molecules. 2023,  DOI
  • Vogt, J. Rosenthal, K. 
    Validation of Easy Fabrication Methods for PDMS-Based Microfluidic
    (Bio) Reactors

    Sci, 2022, DOI
     
  • Steinmann A., Schullehner K., Kohl A., Dickmeis C., Finger M., Hubmann G., Commandeur U., Girhard M., Urlacher V., Lütz S.
    A targeted metabolomics method for extra- and intracellular metabolite quantification covering the complete monolignol and lignan synthesis pathway
    Metabolic Engineering Communications, 2022, DOI
  • Menke M., Behr A., Rosenthal K., Linke D., Kockmann N., Bornscheuer U., Dörr M.
    Development of an Ontology for Biocatalysis
    Chemie Ingenieur Technik, 2022, DOI
  • Rosenthal K., Bornscheuer U., Lütz S.
    Cascades of Evolved Enzymes for the Synthesis of Complex Molecules
    Angewandte Chemie, 2022 DOI
  • Rolf J., Ngo A., Tischler D., Lütz S., Rosenthal K.
    Cell-free protein synthesis for the screening of novel azoreductases and their preferred electron donor
    ChemBioChem, 2022, 23(15) DOI
  • Kinner A., Nerke P., Siedentop R., Steinmetz T., Claassen T., Rosenthal K., Nett M., Pietruszka J., Lütz S.
    Recent Advances in Biocatalysis for Drug Synthesis
    Biomedicines, 2022, 10(5), 964 DOI
  • Siedentop R., Rosenthal K.  
    Industrially Relevant Enzyme Cascades for Drug Synthesis and Their Ecological Assessment
    International Journal of Molecular Science, 2022, 23(7), 3605 DOI
  • Grühn J., Behr A., Eroglu T., Trögel V., Rosenthal K., Kockmann N.
    From Coiled Flow Inverter to Stirred Tank Reactor – Bioprocess Development and Ontology Design
    Chemie Ingenieur Technik, 2022, 94(6), 1-13 DOI
  • Bartsch T.*, Becker M.*, Rolf J.*, Rosenthal K., Lütz S.    (*contributed equally)
    Biotechnological production of cyclic dinucleotides — Challenges and opportunities
    Biotechnology and Bioengineering, 2021 DOI
  • Siedentop R., Claaßen C., Rother D., Lütz S., Rosenthal K. 
    Getting the Most Out of Enzyme Cascades: Strategies to Optimize In Vitro Multi-Enzymatic Reactions
    Catalysts, 2021, 11, 1183 DOI
  • Rolf J., Nerke P., Britner A., Krick S., Lütz S., Rosenthal K. 
    From Cell-Free Protein Synthesis to Whole-Cell Biotransformation: Screening and Identification of Novel α-Ketoglutarate-Dependent Dioxygenases for Preparative-Scale Synthesis of Hydroxy-L-Lysine
    Catalysts, 2021, 11(9), 1038 DOI
  • Kinner A., Rosenthal K., Lütz S. 
    Identification and Expression of New Unspecific Peroxygenases – Recent Advances, Challenges and Opportunities
    Frontiers in Bioengineering and Biotechnology, 2021, 9:705630 DOI
  • Schmitz LM., Hageneier F., Rosenthal K., Busche T., Brandt D., Kalinowski J., Lütz S. 
    Recombinant Expression and Characterization of Novel P450s from Actinosynnema mirum
    Bioorganic & Medicinal Chemistry, 2021, 116241 DOI
  • Becker M., Nikel P., Andexer JN., Lütz S., Rosenthal K. 
    A Multi-Enzyme Cascade Reaction for the Production of 2'3'-cGAMP
    Biomolecules, 2021, 11(4), 590 DOI
  • Schmitz LM., Kinner A., Althoff K., Rosenthal K., Lütz S. 
    Investigation of vitamin D2 and vitamin D3 hydroxylation by Kutzneria albida
    ChemBioChem, 2021, 22, 1-10 DOI
  • Schwarz J., Hubmann G., Rosenthal K., and Lütz S.
    Triaging of Culture Conditions for Enhanced Secondary Metabolite Diversity from Different Bacteria
    Biomolecules, 2021, 11(2), 193 DOI
  • Becker M., Lütz S., and Rosenthal K. (2021)
    Environmental Assessment of Enzyme Production and Purification
    Molecules, 2021, 26(3), 573 DOI
  • Rosenthal K., Becker M., Rolf J., Siedentop R., Hillen M., Nett M., and Lütz S. (2020)
    Catalytic promiscuity of cGAS: A facile enzymatic synthesis of 2’‐3’ linked cyclic dinucleotides
    ChemBioChem, 21, 3225-3228 DOI
     
  • Lütz S. and Liese A. (2020)
    30 Jahre sichere Gentechnik in Deutschland
    Angewandte Chemie, 132, 2-4 DOI
     
  • Schwarz J., Rosenthal K., Snajdrova R., Kittelmann M., and Lütz S. (2020)
    The Development of Biocatalysis as a Tool for Drug Discovery
    CHIMIA, 74(5), 368-377
     
  • Rolf J., Julsing M., Rosenthal K., and Lütz S. (2020)
    A Gram-Scale Limonene Production Process with Engineered Escherichia coli
    Molecules, 2020, 25(8), 1881 DOI
     
  • Sester A., Stüer-Patowsky K., Hiller W., Kloss F., Lütz S. and Nett M. (2020)
    Biosynthetic Plasticity Enables Production of Fluorinated Aurachins
    ChemBioChem, 2020 DOI
  • Rolf J., Siedentop R., Lütz S., and Rosenthal K. (2020)
    Screening and Identification of Novel cGAS Homologues Using a Combination of In Vitro and In Vivo Protein Synthesis
    International Journal of Molecular Science, 21(1): 105
     
  • Schmitz LM., Rosenthal K., Lütz S. (2019)
    Recent Advances in Heme Biocatalysis Engineering
    Biotechnology and Bioengineering DOI
     
  • Schmitz LM., Schäper J., Rosenthal K., Lütz S. (2019)
    Accessing the biocatalytic potential for C-H-activation by targeted genome mining and screening
    ChemCatChem DOI
     
  • Rolf J., Rosenthal K., and Lütz S. 
    Application of Cell-Free Protein Synthesis for Faster Biocatalyst Development
    Catalysts. 2019; 9(2):190 DOI
  • K. Rosenthal, S. Lütz
    Recent developments and challenges of biocatalytic processes in the pharmaceutical industry
    Current Opinion in Green and Sustainable Chemistry 11 (2018), 58-64 DOI 
     
  • A. Worsch, F. K. Eggimann, M. Girhard, C. J. von Bühler, F. Tieves, R. Czaja, A. Vogel, C. Grumaz, K. Sohn, S. Lütz, M. Kittelmann, V. B. Urlacher
    A novel cytochrome P450 monooxygenase from Streptomyces platensis resembles activities of human drug metabolizing P450s
    Biotechnology & Bioengineering 2018 DOI
     
  • M. Schmidt, A. Romanovska, Y. Wolf, T.-D. Nguyen, A. Krupp, H. Tumbrink, J. Lategahn, J. Volmer, D. Rauh, S. Lütz, C. Krumm, J. Tiller
    Insights into the kinetics of the resistance formation of bacteria against ciprofloxacin poly(2-methyl-2-oxazoline) conjugates
    Bioconjugate Chemistry 2018; 29(8): 2671, DOI
  • Grumaz, Christian; Vainshtein, Yevhen; Kirstahler, Philipp; et al
    Draft Genome Sequences of Three Actinobacteria Strains Presenting New Candidate Organisms with High Potentials for Specific P450 Cytochromes
    Genome announcements  Volume: 5  Issue: 28  Published: 2017 Jul, DOI 
     
  • Schmitz, Lisa Marie; Rosenthal, Katrin; Lutz, Stephan
    Enzyme-Based Electrobiotechnological Synthesis
    Advances in biochemical engineering/biotechnology  Published: 2017-Nov-14, DOI 
     
  • Lütz, Stephan
    The First Biocatalytic Carbon-Silicon Bond Formation
    Angewandte Chemie (International Edition)  Volume: 56 Issue: 12 Pages: 3140-3141 Published: 2017-Mar-13, DOI 
  • M. Antunes, F. Eggimann, M. Kittelmann, S. Lütz, S. P. Hanlon, B. Wirz, T. Bachler, M. Winkler
    Human xanthine oxidase recombinant in E. coli: A whole cell catalyst for preparative drug metabolite synthesis
    Journal of Biotechnology Volume 235, Pages 3-10, publiched: 25 March 2016, DOI