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New publication in Molecules
The natural product Aurachin D is a farnesylated quinolone alkaloid known to be active against the causative agent of malaria, Plasmodium spp. Based on the promising activity and results, we investigated how structural modifications affect the bioactivity of this natural product.
In the current publication, aurachin D derivatives with different substituents were generated using whole-cell biotransformation of a recombinant Escherichia coli strain. Modified quinolone substrates were then used in the biotransformation to generate the desired analogs. The derivatives showed, among other things, that natural aurachin D already has an optimal structure for inhibition of the visceral leishmaniasis pathogen.
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