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Faculty of Biochemical and Chemical engineering

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New publication in Biotechnology and Bioengineering

Microtiter Plate Cultivation Systems Enable Chemically Diverse Metabolic Footprints During Bacterial Natural Product Discovery

© TU Dortmund University ​/​ Anton Lindig
Anton Lindig and co-authors publish new article in Biotechnology and Bioengineering on new cultivation methods for the discovery of bacterial natural products.

In the present study, the growth and formation of secondary metabolites (SM) of different bacterial species were compared in different cultivation systems. Microtiter plate culture systems offer optimal conditions for bacterial growth. However, the comparability of SM profiles in these systems is limited. The structure of the detected SM and their derivatives varied depending on the cultivation system. The use of microplate cultivation systems, in particular the 48-well flowerplate, enables efficient parallelization of bacterial cultivation and also offers a higher degree of comparability with stirred-tank bioreactors compared to shake flasks. The use of microplate cultivation systems has therefore proven to be advantageous for the discovery of new natural products.


Here you can find the publication