Microtiter Plate Cultivation Systems Enable Chemically Diverse Metabolic Footprints During Bacterial Natural Product Discovery

In the present study, the growth and formation of secondary metabolites (SM) of different bacterial species were compared in different cultivation systems. Microtiter plate culture systems offer optimal conditions for bacterial growth. However, the comparability of SM profiles in these systems is limited. The structure of the detected SM and their derivatives varied depending on the cultivation system. The use of microplate cultivation systems, in particular the 48-well flowerplate, enables efficient parallelization of bacterial cultivation and also offers a higher degree of comparability with stirred-tank bioreactors compared to shake flasks. The use of microplate cultivation systems has therefore proven to be advantageous for the discovery of new natural products.

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