Combinatorial expression systems for complex genes - A toolbox for efficient catalyst identification.
The project "Combinatorial expression systems for complex genes - A toolbox for efficient catalyst identification" is dedicated to new biocatalysts.
To fully realize the potential of the bioeconomy and industrial biotechnology for more environmentally friendly processes in the chemical and pharmaceutical industries, biological catalysts are needed. Biocatalysts from microorganisms with a high guanosine (G)/cytosine (C) content pose a particular challenge, as this prevents simple manipulation via standard molecular biology. Here, well-characterized and reliably applicable building blocks - so-called biobricks - are needed, which can be easily assembled and modified according to engineering principles. In this project, Dr. Katrin Rosenthal from the Faculty of Bio- and Chemical Engineering at TU Dortmund University and Prof. Dirk Tischler from Ruhr University Bochum are therefore building a joint biobrick collection. This will create a toolbox for synthetic biology that can also be used by other partners and enable further research, such as the rapid screening of new biocatalysts and the development of new production systems in the field of natural product and active ingredient production.